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Abstract

The morbidity and mortality rates associated with breast cancer are a major public health concern globally. The resulting impairment in the patients’ quality of life (QOL) affects their health, symptoms, and well-being in physical, social, psychological, environmental, and sexual functioning. The aim of this study was to systematically review the literature addressing the determinants of QOL in breast cancer patients. A search of 6 electronic medical databases was undertaken. Employing a rigorous systematic protocol, eligible articles were analyzed and a total of 22 studies that met all eligibility criteria were included in the systematic review. The total sample size was 7,041 women ranging from 30 to 66 years. The determinants of QOL were found to cluster into 10 areas. These include the degree of pain, type and stage of cancer treatment, medical health, cognitive and behavioural factors, emotional health, physical activity and appearance, social factors, age and menopausal status, education and employment status, and ethnicity and religion. The types of breast cancer treatment and psychological parameters were the most common determinants of QOL in breast cancer patients. These insights can help formulate proactive interventions that can be used by patients, caregivers, and healthcare professionals to build protective capacities and alleviate challenges to ensure superior quality of life in women with breast cancer.

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