Constant Light Alters Serum Hormone Levels Related to Thyroid Function in Male CD-1 Mice
Disruptions to the circadian rhythm can lead to altered metabolism. Modification of thyroid function may be a reason why circadian misalignment may contribute to future metabolic disorders. We investigated whether circadian disruption through constant light (LL) can lead to variations in hormone levels associated with thyroid function. Mice were exposed to LL or a 12:12 Light:Dark (LD) cycle for 6 weeks; then glucose tolerance and thyroid hormone levels were measured at ZT 6 and ZT 18. There was day/night variation in glucose tolerance, but LL had no effect. LL reduced TSH, increased fT4, and abolished day/night variation in fT3 and leptin. These findings illustrate that LL alters thyroid-related hormones, providing evidence of a link between circadian disruption and thyroid function.
Maroni, M.J., Capri, K.M., Cushman, A.V., Monteiro De Pina, I.K., Chasse, M.H., & Seggio, J.A. (2018). Constant Light Alters Serum Hormone Levels Related to Thyroid Function in Male CD-1 Mice. Chronobiology International, published online June 28, 2018. https://doi.org/10.1080/07420528.2018.1488259
Virtual Commons Citation
Maroni, Marissa J.; Capri, Kimberly M.; Cushman, Alexis V.; Monteiro De Pina, Isabella K.; Chasse, Madison H.; and Seggio, Joseph A. (2018). Constant Light Alters Serum Hormone Levels Related to Thyroid Function in Male CD-1 Mice. In Biological Sciences Faculty Publications. Paper 80.
Available at: http://vc.bridgew.edu/biol_fac/80