The CTLA-4 gene is expressed in placental fibroblasts
In order to elucidate the mechanisms that ensure survival of the allogeneic fetus, we are investigating the expression pattern of genes that are involved in peripheral self-tolerance in tissues at the maternal–fetal interface. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a negative regulator of T cell activation and may modulate peripheral self-tolerance. Previously, we reported the preferential transmission of maternally-inherited shorter alleles at a 3′-UTR microsatellite locus to liveborn children, but random transmission of paternally-inherited alleles, suggesting that CTLA-4 may be involved in the maintenance of tolerance at the maternal–fetal interface. In this report, we demonstrate that CTLA-4 mRNA and protein are indeed expressed in fetal tissues at the maternal–fetal interface throughout gestation.
Kaufman, K., Bowen, J. A., Tsai, A. F., Bluestone, J. A., Hunt, J. S., & Ober, C. (1999). The CTLA-4 gene is expressed in placental fibroblasts. Molecular Human Reproduction, 5(1), 84-87.
Virtual Commons Citation
Kaufman, K.; Bowen, Jeffery; Tsai, A. F.; Bluestone, J. A.; Hunt, J. S.; and Ober, C. (1999). The CTLA-4 gene is expressed in placental fibroblasts. In Biological Sciences Faculty Publications. Paper 29.
Available at: http://vc.bridgew.edu/biol_fac/29