Atomic force microscopes (AFMs) are ubiquitous in research laboratories and have recently been priced for use in teaching laboratories. Here, we review several AFM platforms and describe various biophysical experiments that could be done in the teaching laboratory using these instruments. In particular, we focus on experiments that image biological materials (cells, microtubules, and DNA) and quantify biophysical parameters including membrane tension, persistence length, contour length, and the drag force.
Devenica, L.M., Contee, C., Cabrejo, R., Kurek, M., Deveney, E.F., Carter, A.R. (2016). Biophysical Measurements of Cells, Microtubules, and DNA with an Atomic Force Microscope. American Journal of Physics, 84(4), 301-310. doi: 10.1119/1.4941048
Virtual Commons Citation
Devenica, Luka M.; Contee, Clay; Cabrejo, Raysa; Kurek, Matthew; Deveney, Edward F.; and Carter, Ashley R. (2016). Biophysical Measurements of Cells, Microtubules, and DNA with an Atomic Force Microscope. In Physics Faculty Publications. Paper 27.
Available at: http://vc.bridgew.edu/physics_fac/27