Long-term Wheel-running and Acute 6-h Advances Alter Glucose Tolerance and Insulin Levels in TALLYHO/JngJ Mice
Studies have shown a relationship between circadian rhythm disruptions and type-2 diabetes. This investigation examined the effects of circadian disruption (6-h phase advances) on the progression of diabetes in a type-2 diabetic mouse model – TALLYHO/JngJ – and whether wheel-running can alleviate the effects of the phase advances. 6-h advances alter fasting glucose, glucose tolerance and insulin production. Wheel-running reduced body mass, improved glucose tolerance and reduced insulin in TALLYHO/JngJ and alleviated some of the changes in diabetic symptoms due to 6-h advances. These results indicate that individuals with type-2 diabetes can benefit from physical activity and exercise can be a countermeasure to offset the effects of an acute phase advance.
Nascimento, N.F., Hicks, J.A., Carlson, K.N., Hatzidis, A., Amaral, D.N., Logan, R.W., & Seggio, J.A. (2015). Long-term Wheel-running and Acute 6-h Advances Alter Glucose Tolerance and Insulin Levels in TALLYHO/JngJ Mice. Chronobiology International. 33(1), 108-116. doi: 10.3109/07420528.2015.1108330.
Virtual Commons Citation
Nascimento, Nara F.; Hicks, Jasmin A.; Carlson, Karen N.; Hatzidis, Aikaterini; Amaral, Danielle N.; Logan, Ryan W.; and Seggio, Joseph A. (2016). Long-term Wheel-running and Acute 6-h Advances Alter Glucose Tolerance and Insulin Levels in TALLYHO/JngJ Mice. In Biological Sciences Faculty Publications. Paper 52.
Available at: http://vc.bridgew.edu/biol_fac/52