Title

Long-term Wheel-running and Acute 6-h Advances Alter Glucose Tolerance and Insulin Levels in TALLYHO/JngJ Mice

Publication Date

2016

Document Type

Article

Abstract

Studies have shown a relationship between circadian rhythm disruptions and type-2 diabetes. This investigation examined the effects of circadian disruption (6-h phase advances) on the progression of diabetes in a type-2 diabetic mouse model – TALLYHO/JngJ – and whether wheel-running can alleviate the effects of the phase advances. 6-h advances alter fasting glucose, glucose tolerance and insulin production. Wheel-running reduced body mass, improved glucose tolerance and reduced insulin in TALLYHO/JngJ and alleviated some of the changes in diabetic symptoms due to 6-h advances. These results indicate that individuals with type-2 diabetes can benefit from physical activity and exercise can be a countermeasure to offset the effects of an acute phase advance.

Original Citation

Nascimento, N.F., Hicks, J.A., Carlson, K.N., Hatzidis, A., Amaral, D.N., Logan, R.W., & Seggio, J.A. (2015). Long-term Wheel-running and Acute 6-h Advances Alter Glucose Tolerance and Insulin Levels in TALLYHO/JngJ Mice. Chronobiology International. 33(1), 108-116. doi: 10.3109/07420528.2015.1108330.